Understanding White Blood Cell Disorders: Causes of Leukocytosis, Leukopenia, and Other Abnormalities

 

Leukocytosis
Neutrophilia Neutrophils > 7000/cmm   Causes 1 Bacterial Infection 2 Some Viral Infection       Chicken Pox       Herpes       Simplex 3 Acute inflammations 4 Myocardial Infarction 5 Burns 6 Some Drugs       Epinephrine       Cortisol       Prednisone	Eosinophilia Eosinophils > 400/cmm   Causes 1 Tumor 2 Allergy 3 Infections 4 Malignancy 5 Skin Disorder 6 GIT Disorder 7 Hyper eosinophilic 8 Syndrome 9 Parasitic and Fungal 10 Disease 11 Endocrine 12 Autoimmune Disease	Basophilia Basophils > 100/cmm   Causes 1 Myeloproliferative      2 Neoplasm 3 Carcinoma 4 Lymphoma 5 Allergy 6 Inflammatory conditions 7 Infections      Influenza      Chicken pox      TB      Small Pox 8 IDA 9 Endocrinopathy	Monocytosis Monocytes > 800/cmm   Causes 1 Acute Viral Infection 2 TB 3 Brucellosis 4 Listeriosis 5 Endocarditis 6 Syphilis 7 Viral Infection      Kala Azar      Malaria      Rocky MSF 8 Hodgkin’s Disease 9 Autoimmune Disease 10 Myelomonocytic Leukemia	Lymphocytosis In Adults Lymphocytes              > 4000/cmm, In Children          > 7000/cmm, Infants                > 4000/cmm     Causes 1 Acute Viral Infection 2 Mononucleosis 3 Hepatitis 4 Cytomegaly 5 Rubella 6 Mumps 7 Protozoal Infection 8 Toxoplasmosis 9 American Trypanomiasis 10 Bacterial Infection 11 TB 12 Splenomegaly 13 Post Splenomegaly 14 Chronic/Acute Lymphatic Infection

Leukopenia
Leukopenia Neutrophils < 4000/cmm   Causes 1. Bacterial Infection      Typhoid Fever       TB       Brucella 2. Some Viral Infection       Hepatitis       Influenzas       Rubella 3. Protozoal Infection 4. Some Drugs       Anti-inflammatory (Phenyl but)       Anti-Bacterial (Chloramphenicol)       Anti-Thyroid (Carnidazole)       Hypoglycemic (Carbimazole)       X-Rays/Gamma Rays 5. Autoimmune Disease 6 Low production of BM	Eosinopenia Eosinophils < 40/cmm   Causes 1. Bacterial Infection 2. By stress Reactions 3. Cushing Syndrome 4. By the Use of Steroids 5. Pathological Causes Including Burns and Acute Infection	Neutropenia Basophils <2500/cmm   Causes 1. Chronic          I Aplastic Anemia    II Glycogen Storage Disease    III Parth Syndrome    IV Vit B12 Deficiency    V Congenital Immunological Disorder 2. Transient   I Typhoid   II TB   III Cytomegalovirus    IV Levamisole    V Cefmetazole	Basopenia Monocytes < 20/cmm   Causes 1. Acute Infection 2. Hyperthyroidism 3. Stress Reaction (Pregnancy/MI) 4. Heredity absence of Basophils 5. Prolonged steroids therapy, Chemotherapy, radiation	Lymphocytopenia  Lymphocytes < 1500/cmm   Causes 1. Viral Infection 2. Bacterial Infection 3. Rheumatoid Arthritis 4. Sarcoidosis 5. Iatrogenic causes by medical Treatment 6. Prolong physical Exercise (release of cortisol) 7. Large doses 8. Radiation 9. Some malignancies in BM